Of the direct effects of nuclear weapons, the heat, blast and the ionising radiation are the causes of damage to human beings.
Within a certain distance from the site of explosion, the heat is so intense that practically everything is vaporised. In Hiroshima, all that was left of some humans, sitting on stone benches near the centre of explosion, was their outlines.

Outlines of victims of the nuclear explosion in Hiroshima
Outside the area where wounds are mortal, many humans will suffer
severe burns. Heat radiation on bare skin causes burns directly.
The skin will also be indirectly damaged when their clothes catch
fire.
The thermal radiation causes damage to the eyes so that many people will be blinded by the explosion. For most of them, sight will return within a few minutes, but some will suffer permanent damage to the eyes, such as retina burns.
Many people will also be wounded or killed by the fires that result from the thermal radiation. These fires may grow together and become immense firestorms, spreading out from the site of explosion. Within these areas, even people in underground shelters will die because of heat, lack of oxygen or from carbon monoxide or -dioxide poisoning.
Humans can be killed by the sheer force of the blast if they are close to the explosion. At a greater distance, the shock may cause damage to the lungs or burst eardrums.
Most of the wounds caused by the blast will be indirect. People are most likely to die under collapsing buildings or by being hurled into solid objects. Further extensive damage will be caused to humans by flying shrapnel in the form of shattered glass, brick, concrete or wood.
One of the things that set nuclear weapons apart from conventional arms is that the former kill and wound through radiation. This damage is caused by gamma and neutron radiation in both initial radiation and radioactive fall-out.
The damage caused by radiation is suffered by the cells of the body. When a somatic (body) cell is irradiated, the energy carried by the radiation is transferred to the cell. There is a risk that the DNA molecule contained in the cell is damaged, either directly by the radiation or by so-called free radicals, molecules that are harmful to DNA, that are formed in the cell. Unless the DNA molecule can be repaired, the cell will either die or become a cancer cell.
Pregnant women exposed to high doses of radiation suffer the risk of deformation of their children.
When a human body is exposed to a lethal dose of radiation, three syndromes appear:
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